In the 1930s, thousands of people died of dysentery, pneumonia, pulmonary plague, and sepsis.
"When I woke up just after dawn on September 28, 1928, I certainly didn't plan to revolutionize all medicine by discovering the world's first antibiotic, or bacteria killer. But I suppose that was exactly what I did." - that is what Alexander Fleming, the man who invented penicillin, wrote in this diary.
Benzylpenicillin (penicillin G (PCN G) or penicillin (PCN) is a N-phenylacetamide 6-aminopenicillic acid. It's an antibiotic obtained from the mold of the penicillium fungus. Its action is based on suppressing the synthesis that participates in external envelopes, and it also applies to cells of the bacterial category - benzylpenicillin prevent the proliferation of prokaryotic cells, including cyanobacteria, and also prevent the division of chloroplasts.
In 1929, the well-known British bacteriologist Alexander Fleming conducted a series of experiments on the study of mold fungi. He found that a particular type of mold fungus secretes a specific antibacterial substance, later called penicillin. His experiments were devoted to a detailed study of the effect of bacterial infections on the human body.
After the first staphylococcal cultures were grown during the experiments, Fleming revealed that most of them are prone to infection with the mold fungus Penicillium chrysogenum. The British scientist paid his attention to the area where staphylococcus bacteria did not multiply - just where the mold fungi Penicillium notanum were. Thus, he came to the conclusion that a certain type of mold is capable of producing substances that simply kill bacteria that come into contact with it. The result of the experiments was the isolation of an antimicrobial drug called penicillin. In a word, this would be the first antibiotic of the modern type. See more details on Fleming experiments at http://www.cfop.biz/history-of-penicillin.html.
Penicillin saved a huge number of lives, both during the Second World War and after it. Moreover, the medicine has become the first means, which is able to resist microbes of various classes and species. The discovery and production of penicillin is one of the greatest events in medicine and science of the past century.
Of course, today, there is a great number of various antibiotics. The largest assortment if represented in Canadian Family Pharmacy, but you should remember that most of these drugs are based on the discovery of the medicinal properties of penicillin!
The importance of penicillin in medicine
Subsequently, a huge money was invested in the production of penicillin. The method of production has been improved, and since 1952 cheap penicillin has been used on a world scale. Today, its modifications are widely used for the treatment of serious diseases and infections, which, most likely, would lead to imminent death before the antibiotic discovery. In the whole history of mankind there was no such medicine that would save as many lives as penicillin did.
Properties of Canadian pharmaceuticals of a penicillin group
Antibiotic penicillin suppresses the appearance and development of such pathogenic organisms as:
- tetanus bacillus;
- anthrax stick;
- wand botulism;
- diphtheria bacillus, etc.
This is only a small list of those pathogenic bacteria in which penicillin and other Canadian medications of a penicillin group inhibit vital functions.
The antibiotic effect of penicillin can be bactericidal or bacteriostatic. In the latter case, it is a complete destruction of the pathogens that caused the disease, most often acute and extremely severe. For diseases of moderate severity, antibiotics with a bacteriostatic effect are used - they do not allow bacteria to produce fission.
Penicillin is an antibiotic with a bactericidal effect. Microbes in its structure have a cell wall with the main substance peptidoglycan. This substance gives the bacterial cell stability, not allowing it to die even in very unsuitable conditions. Influencing the cell wall, penicillin destroys its integrity and disables its work.
In the human body, cell membranes do not contain peptidoglycan and therefore the antibiotics of the penicillin group do not have a negative effect on our body. Also, such drugs have a low toxicity.
Penicillins sold in a generic pharmacy online have a wide range of dosages, it is more safe for the human body, since it allows choosing a therapeutic dosage with a specific side effect for a particular patient.
The main part of penicillin is excreted from the body by the kidneys with urine (more than 70%). Some antibiotics of the penicillin group are secreted with the help of the biliary system, that is, they exit with bile.
List and classification of penicillins
Drugs of the penicillin group contain the beta-lactam ring, that is why they belong to beta-lactamam drugs.
Penicillin has been used for more than 80 years, so some microorganisms have developed resistance to this antibiotic in the form of a beta-lactamase enzyme. The mechanism of the enzyme's work consists in combining the hydrolytic enzyme of the pathogenic bacterium with the beta-lactam ring, which in turn facilitates their binding, and as a result, inactivates the drug.
To date, Canadian Family Pharmacy sells the following types of penicillin medications.
Natural short-acting antibiotics
Natural antibiotics do not have beta-lactamase inhibitors, that is why they are never used against diseases caused by staphylococcus.
Benzylpenicillin is used for the treatment of:
- croupous pneumonia;
- diseases of the genitourinary system;
- skin infections;
- wound infections;
- ENT diseases.
Natural antibiotics with prolonged action
Benzylpenicillin benzathine is used in the following cases:
- inflammation of the tonsils;
- infections of wounds;
- scarlet fever.
- to prevent complications after surgeries.
Buying drugs from Canada, you may be sure in their quality and safety. Here you can always find cheaper penicillin antibiotics with the same efficiency!